Gene information
Official symbol C5
Official full name complement C5
Gene type protein-coding gene
Chromosome9q33.2
Alias symbolCPAMD4|C5a|C5b
Gene familyReceptor ligands|C3 and PZP like, alpha-2-macroglobulin domain containing|Complement system activation components
Resources
Entrez Gene 727
HGNC HGNC:1331
Ensembl ENSG00000106804
Vega OTTHUMG00000020579
UCSC uc004bkv.4
GO terms: 55 records
GO Description Category LogP Number of genes Detail
GO:0001664 G protein-coupled receptor binding GO Molecular Functions -22.7408810 35 More
GO:0001701 in utero embryonic development GO Biological Processes -8.76987260 44 More
GO:0001819 positive regulation of cytokine production GO Biological Processes -44.1872667 64 More
GO:0002250 adaptive immune response GO Biological Processes -8.22919489 29 More
GO:0002252 immune effector process GO Biological Processes -24.2648770 43 More
GO:0002253 activation of immune response GO Biological Processes -3.86084748 14 More
GO:0002443 leukocyte mediated immunity GO Biological Processes -15.2263375 27 More
GO:0002449 lymphocyte mediated immunity GO Biological Processes -8.72662877 18 More
GO:0002455 humoral immune response mediated by circulating immunoglobulin GO Biological Processes -5.71650362 10 More
GO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO Biological Processes -11.9339394 22 More
GO:0002683 negative regulation of immune system process GO Biological Processes -26.6415063 77 More
GO:0002685 regulation of leukocyte migration GO Biological Processes -36.943236 43 More
GO:0002686 negative regulation of leukocyte migration GO Biological Processes -7.70467721 14 More
GO:0004857 enzyme inhibitor activity GO Molecular Functions -18.4005452 35 More
GO:0004866 endopeptidase inhibitor activity GO Molecular Functions -20.0646267 27 More
GO:0005125 cytokine activity GO Molecular Functions -54.7097150 57 More
GO:0005126 cytokine receptor binding GO Molecular Functions -41.4908940 50 More
GO:0006935 chemotaxis GO Biological Processes -33.1726887 55 More
GO:0006954 inflammatory response GO Biological Processes -86.5569367 100 More
GO:0006956 complement activation GO Biological Processes -7.12107226 12 More
GO:0006957 complement activation, alternative pathway GO Biological Processes -3.04620727 3 More
GO:0006958 complement activation, classical pathway GO Biological Processes -5.86439052 10 More
GO:0006959 humoral immune response GO Biological Processes -20.5068158 33 More
GO:0009792 embryo development ending in birth or egg hatching GO Biological Processes -12.9988944 72 More
GO:0010466 negative regulation of peptidase activity GO Biological Processes -24.1438543 35 More
GO:0010575 positive regulation of vascular endothelial growth factor production GO Biological Processes -10.362168 13 More
GO:0010951 negative regulation of endopeptidase activity GO Biological Processes -24.7873219 35 More
GO:0016064 immunoglobulin mediated immune response GO Biological Processes -6.28897630 13 More
GO:0019724 B cell mediated immunity GO Biological Processes -7.00231964 14 More
GO:0030162 regulation of proteolysis GO Biological Processes -41.2267045 73 More
GO:0030414 peptidase inhibitor activity GO Molecular Functions -19.6181890 27 More
GO:0030545 signaling receptor regulator activity GO Molecular Functions -87.4728446 102 More
GO:0030546 signaling receptor activator activity GO Molecular Functions -90.4065983 101 More
GO:0032102 negative regulation of response to external stimulus GO Biological Processes -54.2675416 110 More
GO:0032642 regulation of chemokine production GO Biological Processes -25.2850711 37 More
GO:0032722 positive regulation of chemokine production GO Biological Processes -22.4503100 21 More
GO:0040013 negative regulation of locomotion GO Biological Processes -30.7871461 81 More
GO:0042330 taxis GO Biological Processes -33.0828571 55 More
GO:0043009 chordate embryonic development GO Biological Processes -11.8113315 68 More
GO:0043086 negative regulation of catalytic activity GO Biological Processes -41.1437610 130 More
GO:0045765 regulation of angiogenesis GO Biological Processes -63.6171248 109 More
GO:0045766 positive regulation of angiogenesis GO Biological Processes -39.3444092 63 More
GO:0045861 negative regulation of proteolysis GO Biological Processes -27.9905009 43 More
GO:0048018 receptor ligand activity GO Molecular Functions -91.0736151 101 More
GO:0050778 positive regulation of immune response GO Biological Processes -17.2528761 40 More
GO:0050920 regulation of chemotaxis GO Biological Processes -36.3269885 43 More
GO:0050922 negative regulation of chemotaxis GO Biological Processes -8.57011989 17 More
GO:0051346 negative regulation of hydrolase activity GO Biological Processes -26.0030636 42 More
GO:0052547 regulation of peptidase activity GO Biological Processes -35.5643317 55 More
GO:0052548 regulation of endopeptidase activity GO Biological Processes -34.9486589 53 More
GO:0060326 cell chemotaxis GO Biological Processes -35.3882493 41 More
GO:0061134 peptidase regulator activity GO Molecular Functions -19.3582235 29 More
GO:0061135 endopeptidase regulator activity GO Molecular Functions -19.1908633 27 More
GO:1901342 regulation of vasculature development GO Biological Processes -64.8504074 111 More
GO:1904018 positive regulation of vasculature development GO Biological Processes -39.3444092 63 More
KEGG pathways: 8 records
KEGG Description Category LogP Number of genes Detail
hsa04080 Neuroactive ligand-receptor interaction KEGG Pathway -22.6219922 65 More
hsa04610 Complement and coagulation cascades KEGG Pathway -50.1154932 39 More
hsa04936 Alcoholic liver disease KEGG Pathway -13.3477535 19 More
hsa05020 Prion disease KEGG Pathway -2.47073365 10 More
hsa05133 Pertussis KEGG Pathway -13.2270528 15 More
hsa05150 Staphylococcus aureus infection KEGG Pathway -9.38905356 13 More
hsa05171 Coronavirus disease - COVID-19 KEGG Pathway -24.8179886 34 More
hsa05322 Systemic lupus erythematosus KEGG Pathway -4.88971598 10 More
Drug-Gene interaction
view
Related drugs: 7 records
Related study: 1 record
Molecular factor Omics type Application Objective MI type Reference
complement C5 proteomics medium predictor left ventricular dysfunction[prognosis (bad)] acute myocardial infarction Brenner R et al. Biomark Med. 2014
All rights reserved: Soochow University Center for Systems Biology